|
KMID : 1123920020160020327
|
|
Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 2 p.327 ~ p.331
|
|
|
Immuno-modulatory and Anti-carcinogenic Property of Cordyceps militaris and Paecilomyces japonicus
|
|
Jung Han-Sol
Kwon Jin
Lee Tae-Gyu
Lee Kwang-Gyu
Oh Chan-Ho
|
|
|
Abstract
|
|
|
|
The purpose of this research was to investigate the immuno-modulatory effect and anti-carcinogenic property of Cordyceps militaris(CM) and/or Paecilomyces japonicus (PJ). The proliferation of cultured splenocytes and thymocytes were enhanced by the addition of 10 ㎍/ml of CM and/or PJ. B lymphocytes subpopulation in splenocytes were increased both CM and/or PJ administered(p.o. for 7 days)-mice. Thymic T lymphocytes, especially TH cells were significantly increased in CM-administered mice. CM and/or PJ treatment inhibited the cell viability of L 1210 mouse leukemia and HL60 human leukemia cells and induced the apoptosis of L1210 and HL60 cells. In addition, CM and/or PJ increased the hemaggutination(HA) titer against SRBC. These results suggest that CM and/or PJ have an immuno-modulatory action and anti-carcinogenic property.
|
|
|
KEYWORD
|
|
|
Cordyceps militaris, Paecilomyces japonicus, splenocyte, thymocyte, L1210 cell, HL60 cell
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|